OR27-07 11-oxygenated C19 Steroids in Normal Weight, Overweight, and Hyperandrogenic Girls
نویسندگان
چکیده
منابع مشابه
11-Oxygenated C19 Steroids Are the Predominant Androgens in Polycystic Ovary Syndrome
Context Androgen excess is a defining feature of polycystic ovary syndrome (PCOS), but the exact origin of hyperandrogenemia remains a matter of debate. Recent studies have highlighted the importance of the 11-oxygenated C19 steroid pathway to androgen metabolism in humans. In this study, we analyzed the contribution of 11-oxygenated androgens to androgen excess in women with PCOS. Methods On...
متن کاملA new dawn for androgens: Novel lessons from 11-oxygenated C19 steroids.
The abundant adrenal C19 steroid 11β-hydroxyandrostenedione (11OHA4) has been written off as a dead-end product of adrenal steroidogenesis. However, recent evidence has demonstrated that 11OHA4 is the precursor to the potent androgenic 11-oxygenated steroids, 11-ketotestosterone and 11-ketodihydrotestosterone, that bind and activate the human androgen receptor similarly to testosterone and DHT....
متن کاملPaper chromatography of C19 steroids.
The successful use of paper chromatography for t.he separation of corticoids (2) suggested the general usefulness of this procedure for relat,ed compounds. Two procedures for t.he separation of cardiac glycosides and aglycones have been described (3, 1). Preliminary reports (5, G) and a reference (7) have been made on methods for other steroid hormones. This paper describes an effective system ...
متن کاملWeekend and weekday patterns of physical activity in overweight and normal-weight adolescent girls.
OBJECTIVE To describe the patterns (specifically comparing weekdays and weekends classified by intensities) of physical activity (PA) measured by accelerometry in adolescent girls. RESEARCH METHODS AND PROCEDURES Healthy sixth grade girls (n=1603), 11 to 12 years old, were randomly recruited from 36 schools participating in the Trial of Activity in Adolescent Girls. Age, ethnicity, socioecono...
متن کاملThe effect of puberty on fat oxidation rates during exercise in overweight and normal-weight girls.
Excess weight is often associated with insulin resistance (IR) and may disrupt fat oxidation during exercise. This effect is further modified by puberty. While studies have shown that maximal fat oxidation rates (FOR) during exercise decrease with puberty in normal-weight (NW) and overweight (OW) boys, the effect of puberty in NW and OW girls is unclear. Thirty-three NW and OW girls ages 8-18 y...
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ژورنال
عنوان ژورنال: Journal of the Endocrine Society
سال: 2020
ISSN: 2472-1972
DOI: 10.1210/jendso/bvaa046.1345